Day 1 :
Colorado State University, USA
Keynote: Prevention of Transfusion-Transmitted Parasitic Infections: Preventing Transfusion-Transmission of Malaria in Africa
Time : 09:30-10:10
Dr. Goodrich received his BS in Chemistry from The Ohio State University and a PhD in Chemistry from the California Institute of Technology. As the Executive Director of the Infectious Disease Research Center (IDRC) at Colorado State University, Dr. Goodrich has responsibility for oversight of the Biopharmaceutical Manufacturing and Academic Resource Center (BioMARC), Regional Biocontainment Laboratory (RBL) and the Research Innovation Center (RIC). He also holds a faculty appointment as Professor in the Department of Microbiology, Immunology and Pathology at Colorado State University and an Adjunct Professor of Chemistry at The Ohio State University. Dr. Goodrich has worked in medical research for over 29 years during which he has managed research staff and development programs in the fields of transfusion and transplantation medicine and pathogen reduction technologies. He has been awarded over 58 patents covering technology in these areas and has co-authored over 200 peer reviewed articles and abstracts.
Transfusion-transmitted parasitic diseases remain a major obstacle to the provision of safe blood products for support of patients in many parts of the world. Transfusion-transmitted malaria in parts of Africa provides an example of the magnitude of this issue. Studies have demonstrated that 14-28% of the patients presenting for transfusion in Ghana are susceptible to transmission of malaria through the blood products that they receive. Screening of blood donations to prevent transmission is not feasible, as this could eliminate up to 50% of the donated blood products in a region where blood availability and supply is an issue. Recently developed methods for treating blood products prior to transfusion to inactivate pathogens that may be present have been implemented in various regions of the world. In vitro testing has demonstrated the efficacy of these processes for a number of bacterial, viral and parasitic agents. Until recently, however, the processes have been limited to treatment of platelet and plasma blood products. In regions of sub-Saharan Africa and other parts of the world, whole blood that has not been separated into components represents the major transfused product, which is given primarily for treatment of conditions such as post-partum bleeding, traumatic injury or support of patients with sickle cell disease. The ability to prevent transmission of disease in this setting would require treatment of all components of blood and preferably whole blood in order to keep the process simple and remain cost-effective. This presentation will focus on results from a clinical study on the prevention of transfusion transmitted malaria in Ghana and report the results of a clinical investigation of this approach and subsequent implementation of this method in large scale in the region. In addition, applicability to other disease transmission events for bacterial, viral and parasitic agents will be discussed.
Vanderbilt University, USA
Time : 10:10-10:50
David Wright (b. 1965) attended Tulane University in New Orleans, Louisiana where he received a B.S. in Chemistry and a B.A. in Classical Languages and Ancient History. He pursued his graduate work at the Massachusetts Institute of Technology in Cambridge, MA under the supervision of Prof. William. H. Orme-Johnson, focused on understanding the structure and function of the FeMo-cofactor of the enzyme nitrogenase. David joined the faculty of Vanderbilt University in 2001. His research focus spans areas ranging from heme detoxification in hemophagous parasitic infectious diseases to developing tools and diagnostics for low-resource settings to understanding the biomineralization of novel materials in biological systems.
There are over 2 billion people on the planet who live on less than $2.00 a day. What happens when they get sick? How can they afford to go to the doctor and find out why they don’t fell well? The solutions for the diagnostic needs of the people living at the bottom of the healthcare pyramid can be found in our children's toy box, the kitchen counter, or on the poster advertising this weekend’s rave. The creation of ASSURED diagnostic devices requires new, non-traditional approaches for the development of effective tests for parasitic diseases. In this talk, we will highlight how the principles of everyday objects and phenomena can be adapted for highly sensitive and specific medical tests.
This talk will demonstrate how three different everyday objects have been successfully adopted as low resource diagnostics. The concepts originate from origami, the ancient art of Japanese paper folding, coffee rings, like those left on the kitchen counter, and glow sticks, a favorite children’s' toy. These new devices provide new solutions to the challenges of field deployable diagnostic tests for the detection of asymptomatic malaria.
Universidad de Zaragoza, Mexico
M. Gonzalez Ronquillo, Doctor in Veterinary Medicine at the Universidad de Zaragoza, Spain. FAO Voluntary in AGA division, Rome Italy, and Fulbright in the US Dairy Forage Research, I worked with natural extracts as antihelmintics properties, ruminant nutrition and Curve lactation models in small ruminants.