Amany Ahmed Abd El-Aal
Cairo University, Egypt
Title: Immunomodulatory impression of anti and pro-inflammatory cytokines in relation to humoral immunity in human scabies
Biography
Biography: Amany Ahmed Abd El-Aal
Abstract
The chief manifestations of scabies are mediated through hypersensitivity-like reactions and immune responses which are so far not well understood and remain poorly characterized. The aim of this study is to investigate the role of inflammatory cytokines in relation to humoral immunity in patients with scabies. Serum levels of total IgE, specific IgG, IL-10, IL-6, INF-γ, and TNF-α were investigated in a cross-sectional study including 37 patients with manifestations suggestive of scabies and serologically positive for anti Sarcoptes IgG, in addition to 20 healthy controls. The median value of total IgE was 209 (range, 17-1219 IU/mL), reflecting its wide range within our cases. IL-10 showed significant higher levels (28.7±13.9) in infected cases than in controls (17.4±11.32). A positive correlation was reported between total IgE and severity of manifestations (r=0.429, P<0.005). A significant positive correlation was observed between total IgE and both IgG and IL-6. On the contrary, a negative correlation was recorded between IL-6 and TNF-α which makes us, suggested anti-inflammatory rather than pro-inflammatory effect of IL-6 in the current study. Moreover, a negative correlation was noticed between the anti-inflammatory cytokine IL-10 and severity of manifestations, specific IgG, total IgE and INF-γ. Therefore, the current study theorized a regulatory role of IL-10 in inflammatory responses of scabietic patients, suggesting further future analysis of its therapeutic potential.