Yong-long Li
Huazhong University of Science and Technology, China
Title: Plasmodium yoelii infection inhibited murine leukemia WEHI-3 cells by promotion of immune responses in vivo
Biography
Biography: Yong-long Li
Abstract
Leukemia is a malignancy disorder in leukocytes which occurs in animals as well as human. Current therapeutic for the disease remains unsatisfactory and fatality percentage is higher. Developing new therapeutic strategies for the disease is needed. It has been reported that malaria parasite infection is efficacious to combat some cancers in experimental animals. In the present paper, we studied anti-leukemia activity of malaria parasite Plasmodium yoelii infection in leukemia WEHI-3 cells bearing mice and found that P. yoelii infection significantly inhibited the development of leukemia WEHI-3 cells in the mice and the neoplasm cells infiltrations in the liver and spleen were obviously reduced. Also we demonstrated that malaria infection provided anti-leukemia activity by promotion of immune responses which included increasing percentages cell surface markers of T cell (CD3e) and B cell (CD19), decreasing the amount of the percentage of the cell surface markers of monocytes, (CD11b) and macrophages (Mac-3), inducing the secretion of IFN-r and TNF-α and promotion of natural killer (NK) cell activity.